Polarization diversity of human CD4+ stem cell memory T cells
M Takeshita, K Suzuki, Y Kassai, M Takiguchi… - Clinical …, 2015 - Elsevier
T cells are considered to develop through three stages, from naïve T (Tn) into central
memory T (Tcm) and finally into effector memory T (Tem). Among the subsets of Tn, stem cell
memory T (Tscm) were recently found to be the least developed memory subset. While this
subset was revealed to possess self-reproducibility and multipotentiality, little is known
about the relationship between development and polarity. We conducted transcriptome
analysis of human CD4+ T subsets and found that Tscm was a clearly distinct subset …
memory T (Tcm) and finally into effector memory T (Tem). Among the subsets of Tn, stem cell
memory T (Tscm) were recently found to be the least developed memory subset. While this
subset was revealed to possess self-reproducibility and multipotentiality, little is known
about the relationship between development and polarity. We conducted transcriptome
analysis of human CD4+ T subsets and found that Tscm was a clearly distinct subset …