[HTML][HTML] Structure and function of SET and MYND domain-containing proteins

N Spellmon, J Holcomb, L Trescott… - International journal of …, 2015 - mdpi.com
N Spellmon, J Holcomb, L Trescott, N Sirinupong, Z Yang
International journal of molecular sciences, 2015mdpi.com
SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-
DEAF1) domain-containing proteins (SMYD) have been found to methylate a variety of
histone and non-histone targets which contribute to their various roles in cell regulation
including chromatin remodeling, transcription, signal transduction, and cell cycle control.
During early development, SMYD proteins are believed to act as an epigenetic regulator for
myogenesis and cardiomyocyte differentiation as they are abundantly expressed in cardiac …
SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-DEAF1) domain-containing proteins (SMYD) have been found to methylate a variety of histone and non-histone targets which contribute to their various roles in cell regulation including chromatin remodeling, transcription, signal transduction, and cell cycle control. During early development, SMYD proteins are believed to act as an epigenetic regulator for myogenesis and cardiomyocyte differentiation as they are abundantly expressed in cardiac and skeletal muscle. SMYD proteins are also of therapeutic interest due to the growing list of carcinomas and cardiovascular diseases linked to SMYD overexpression or dysfunction making them a putative target for drug intervention. This review will examine the biological relevance and gather all of the current structural data of SMYD proteins.
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