[HTML][HTML] ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading

CY Wang, S Jenkitkasemwong, S Duarte… - Journal of Biological …, 2012 - ASBMB
ZIP8 (SLC39A8) belongs to the ZIP family of metal-ion transporters. Among the ZIP proteins,
ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and
cadmium. Here we investigated the iron transport ability of ZIP8, its subcellular localization,
pH dependence, and regulation by iron. Transfection of HEK 293T cells with ZIP8 cDNA
enhanced the uptake of 59 Fe and 65 Zn by 200 and 40%, respectively, compared with
controls. Excess iron inhibited the uptake of zinc and vice versa. In RNA-injected Xenopus …