Heme regulation of HeLa cell transferrin receptor number.

JH Ward, I Jordan, JP Kushner, J Kaplan - Journal of Biological Chemistry, 1984 - ASBMB
The number of diferic transferrin receptors on HeLa cells decreases when cells are grown in
iron-supplemented media. The experiments reported here suggest that heme is the iron-
containing compound which serves as the signal for receptor number regulation. When
HeLa cells were grown in the presence of hemin, transferrin receptor number decreased to a
greater degree than when cells were grown in equivalent amounts of iron supplied as ferric
ammonium citrate. Incubation of cells in conditions which increased cellular heme content …