The upper limit for the size of the human antidextran combining site

EA Kabat - The Journal of Immunology, 1960 - journals.aai.org
EA Kabat
The Journal of Immunology, 1960journals.aai.org
With four human antidextran sera of 1, 6 specificity isomaltoheptaose was not significantly
better as an inhibitor than isomaltohexaose, but with a fifth antiserum the heptasaccharide
was slightly better. The data indicate that in most instances the upper limit in size for most of
the antibody combining sites is complementary to a hexasaccharide but that in one instance
a detectable amount of antibody complementary to a heptasaccharide was found. A Russian
and an American clinical dextran gave identical quantitative precipitin curves with two …
Summary
With four human antidextran sera of 1,6 specificity isomaltoheptaose was not significantly better as an inhibitor than isomaltohexaose, but with a fifth antiserum the heptasaccharide was slightly better. The data indicate that in most instances the upper limit in size for most of the antibody combining sites is complementary to a hexasaccharide but that in one instance a detectable amount of antibody complementary to a heptasaccharide was found. A Russian and an American clinical dextran gave identical quantitative precipitin curves with two human antidextran sera of 1,6 specificity.
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