[HTML][HTML] Iron, inflammation and invasion of cancer cells

E Fischer-Fodor, N Miklasova, I Berindan-Neagoe… - Clujul …, 2015 - ncbi.nlm.nih.gov
E Fischer-Fodor, N Miklasova, I Berindan-Neagoe, B Saha
Clujul medical, 2015ncbi.nlm.nih.gov
Chronic inflammation is associated with the metastasis of tumor cells evolving from a benign
tumor to disseminating cancer. Such a metastatic progression is fostered by the
angiogenesis propelled by various mediators interacting at the site of tumor growth.
Angiogenesis causes two major changes that are assisted by altered glycosylation and neo-
antigen presentation by the cancer cells. The angiogenesis-promoted pathological changes
include enhanced inflammation and degradation of tissue matrices releasing tumor cells …
Abstract
Chronic inflammation is associated with the metastasis of tumor cells evolving from a benign tumor to disseminating cancer. Such a metastatic progression is fostered by the angiogenesis propelled by various mediators interacting at the site of tumor growth. Angiogenesis causes two major changes that are assisted by altered glycosylation and neo-antigen presentation by the cancer cells. The angiogenesis-promoted pathological changes include enhanced inflammation and degradation of tissue matrices releasing tumor cells from the site of its origin. The degraded tumor cells release the neo-antigens resulting from altered glycosylation. Presentation of neo-antigens to T cells escalates metastasis and inflammation. Inflammasome activation and inflammation in several infections are regulated by iron. Based on the discrete reports, we propose a link between iron, inflammation, angiogenesis and tumor growth. Knowing the link better may help us formulate a novel strategy for cancer immunotherapy.
ncbi.nlm.nih.gov