The oxytocin receptor has been suggested to be involved in energy metabolism, such as
food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient
(Oxtr−/−) male mice exhibited late-onset obesity with increases in abdominal fat pads and
fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr−/−
mice were not significantly different as compared with wild-type mice. In contrast, brown
adipose tissue in Oxtr−/− mice contained large lipid droplets and cold-induced …