The GHRH+ arginine stimulated pituitary GH secretion in children and adults with Prader–Willi syndrome shows age-and BMI-dependent and genotype-related …
E Marostica, G Grugni, G De Nicolao, N Marazzi… - Growth Hormone & IGF …, 2013 - Elsevier
Objective The quantitative and qualitative aspects of the pituitary response in children and
adults with Prader–Willi syndrome (PWS) are compared in order to verify the possible age-
dependent and genotype-related differences in terms of GH secretion. Design 29 young
subjects (21 males and 8 females) and 65 adults (24 males and 41 females) with PWS were
studied. All subjects underwent a standard GH Releasing Hormone (GHRH 1-29, 1 μg/kg as
iv bolus at 0 minutes)+ arginine (0.5 g/kg) test. Peak GH values, standard GH area under the …
adults with Prader–Willi syndrome (PWS) are compared in order to verify the possible age-
dependent and genotype-related differences in terms of GH secretion. Design 29 young
subjects (21 males and 8 females) and 65 adults (24 males and 41 females) with PWS were
studied. All subjects underwent a standard GH Releasing Hormone (GHRH 1-29, 1 μg/kg as
iv bolus at 0 minutes)+ arginine (0.5 g/kg) test. Peak GH values, standard GH area under the …