[HTML][HTML] Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the …

WC Liang, X Wu, FV Peale, CV Lee, YG Meng… - Journal of Biological …, 2006 - ASBMB
To fully assess the role of VEGF-A in tumor angiogenesis, antibodies that can block all
sources of vascular endothelial growth factor (VEGF) are desired. Selectively targeting tumor-
derived VEGF overlooks the contribution of host stromal VEGF. Other strategies, such as
targeting VEGF receptors directly or using receptor decoys, result in inhibiting not only VEGF-
A but also VEGF homologues (eg placental growth factor, VEGF-B, and VEGF-C), which may
play a role in angiogenesis. Here we report the identification of novel anti-VEGF antibodies …