[HTML][HTML] Decay-accelerating Factor Induction on Vascular Endothelium by Vascular Endothelial Growth Factor (VEGF) Is Mediated via a VEGF Receptor-2 (VEGF-R2) …

JC Mason, R Steinberg, EA Lidington… - Journal of Biological …, 2004 - ASBMB
Decay-accelerating factor (DAF), a membrane-bound complement regulatory protein, is up-
regulated on endothelial cells (ECs) following treatment with vascular endothelial growth
factor (VEGF), providing enhanced protection from complement-mediated injury. We
explored the signaling pathways involved in this response. Incubation of human umbilical
vein ECs with VEGF induced a 3-fold increase in DAF expression. Inhibition by flk-1 kinase
inhibitor SU1498 and failure of placental growth factor (PlGF) to up-regulate DAF confirmed …