RS domains contact the pre-mRNA throughout spliceosome assembly

KJ Hertel, BR Graveley - Trends in biochemical sciences, 2005 - cell.com
Trends in biochemical sciences, 2005cell.com
SR proteins are essential metazoan splicing factors that contain an RNA-binding domain
and an arginine/serine-rich domain that functions to promote assembly of the spliceosome.
The prevailing model over the past several years suggests that the RS domains function as
protein-interaction domains. However, two new papers from Green et al. demonstrate that
these RS domains directly contact the pre-mRNA within the functional spliceosome. The
sequential character of these contacts suggests that RS domain interactions with RNA …
SR proteins are essential metazoan splicing factors that contain an RNA-binding domain and an arginine/serine-rich domain that functions to promote assembly of the spliceosome. The prevailing model over the past several years suggests that the RS domains function as protein-interaction domains. However, two new papers from Green et al. demonstrate that these RS domains directly contact the pre-mRNA within the functional spliceosome. The sequential character of these contacts suggests that RS domain interactions with RNA promote spliceosome assembly.
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