Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease

K Sharma, B Karl, AV Mathew, JA Gangoiti… - Journal of the …, 2013 - journals.lww.com
Diabetic kidney disease is the leading cause of ESRD, but few biomarkers of diabetic kidney
disease are available. This study used gas chromatography-mass spectrometry to quantify
94 urine metabolites in screening and validation cohorts of patients with diabetes mellitus
(DM) and CKD (DM+ CKD), in patients with DM without CKD (DM–CKD), and in healthy
controls. Compared with levels in healthy controls, 13 metabolites were significantly reduced
in the DM+ CKD cohorts (P≤ 0.001), and 12 of the 13 remained significant when compared …