[HTML][HTML] Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites
Antigen-mediated cross-linking of Immunoglobulin E (IgE) bound to mast cells/basophils via
FcɛRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not
mice, dendritic cells (DCs) also express FcɛRI that is constitutively occupied with IgE. In
contrast to mast cells/basophils, the consequences of IgE/FcɛRI signals for DC function
remain poorly understood. We show that humanized mice that express FcɛRI on DCs carry
IgE like non-allergic humans and do not develop spontaneous allergies. Antigen-specific …
FcɛRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not
mice, dendritic cells (DCs) also express FcɛRI that is constitutively occupied with IgE. In
contrast to mast cells/basophils, the consequences of IgE/FcɛRI signals for DC function
remain poorly understood. We show that humanized mice that express FcɛRI on DCs carry
IgE like non-allergic humans and do not develop spontaneous allergies. Antigen-specific …