[HTML][HTML] Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice
AR Folgueras, A Fueyo, O Garcia-Suarez, J Cox… - Journal of biological …, 2008 - ASBMB
Matrix metalloproteinases (MMPs) have been implicated in a variety of human diseases,
including neuroimmunological disorders such as multiple sclerosis. However, the recent
finding that some MMPs play paradoxical protective roles in these diseases has made
necessary the detailed study of the specific function of each family member in their
pathogenesis. To determine the relevance of collagenase-2 (MMP-8) in experimental
autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, we have …
including neuroimmunological disorders such as multiple sclerosis. However, the recent
finding that some MMPs play paradoxical protective roles in these diseases has made
necessary the detailed study of the specific function of each family member in their
pathogenesis. To determine the relevance of collagenase-2 (MMP-8) in experimental
autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, we have …