[HTML][HTML] T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions
DK Cole, KM Miles, F Madura, CJ Holland… - Journal of Biological …, 2014 - ASBMB
αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged
(CDR3). TCR ligands compose a presentation platform (major histocompatibility complex
(MHC)) and a variable antigenic component consisting of a short" foreign" peptide. The
sequence of events when the TCR engages its peptide-MHC (pMHC) ligand remains
unclear. Some studies suggest that the germ line elements of the TCR engage the MHC …
(CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged
(CDR3). TCR ligands compose a presentation platform (major histocompatibility complex
(MHC)) and a variable antigenic component consisting of a short" foreign" peptide. The
sequence of events when the TCR engages its peptide-MHC (pMHC) ligand remains
unclear. Some studies suggest that the germ line elements of the TCR engage the MHC …