[HTML][HTML] MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development
D Yan, X Da Dong, X Chen, L Wang, C Lu… - Journal of Biological …, 2009 - ASBMB
MicroRNAs (miRNAs) are endogenous short (∼ 22) nucleotide RNAs that regulate gene
function by modification of target mRNAs. miRNA-1 (miR-1) and miRNA-206 (miR-206) are
highly expressed in skeletal muscle. Due to the tissue-specific nature of miR-1/206 for
skeletal muscles, we investigated the role of miR-1/206 in the development of
rhabdomyosarcoma. Initially, we demonstrated that miR-1/206 expression was suppressed
in rhabdomyosarcomas and found at very low levels in a rhabdomyosarcoma RD cell line …
function by modification of target mRNAs. miRNA-1 (miR-1) and miRNA-206 (miR-206) are
highly expressed in skeletal muscle. Due to the tissue-specific nature of miR-1/206 for
skeletal muscles, we investigated the role of miR-1/206 in the development of
rhabdomyosarcoma. Initially, we demonstrated that miR-1/206 expression was suppressed
in rhabdomyosarcomas and found at very low levels in a rhabdomyosarcoma RD cell line …