Generation of improved humanized mouse models for human infectious diseases
MA Brehm, MV Wiles, DL Greiner, LD Shultz - Journal of immunological …, 2014 - Elsevier
The study of human-specific infectious agents has been hindered by the lack of optimal
small animal models. More recently development of novel strains of immunodeficient mice
has begun to provide the opportunity to utilize small animal models for the study of many
human-specific infectious agents. The introduction of a targeted mutation in the IL2 receptor
common gamma chain gene (IL2rg null) in mice already deficient in T and B cells led to a
breakthrough in the ability to engraft hematopoietic stem cells, as well as functional human …
small animal models. More recently development of novel strains of immunodeficient mice
has begun to provide the opportunity to utilize small animal models for the study of many
human-specific infectious agents. The introduction of a targeted mutation in the IL2 receptor
common gamma chain gene (IL2rg null) in mice already deficient in T and B cells led to a
breakthrough in the ability to engraft hematopoietic stem cells, as well as functional human …
