Design of clinical trials in acute kidney injury: a report from an NIDDK workshop—prevention trials

MD Okusa, BA Molitoris, PM Palevsky… - Clinical Journal of the …, 2012 - journals.lww.com
AKI is an important clinical problem that has become increasingly more common. Mortality
rates associated with AKI remain high despite advances in supportive care. Patients
surviving AKI have increased long-term mortality and appear to be at increased risk of
developing CKD and progressing to ESRD. No proven effective pharmacologic therapies
are currently available for the prevention or treatment of AKI. Advances in addressing this
unmet need will require the development of novel therapeutic agents based on precise …