Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors
G Keller, C Paige, E Gilboa, EF Wagner - Nature, 1985 - nature.com
G Keller, C Paige, E Gilboa, EF Wagner
Nature, 1985•nature.comBone marrow cells infected with retroviral vectors carrying the bacterial neomycin resistance
(neo) gene as a marker were used for long-term reconstitution of the haematopoietic system
of irradiated mice. The neo gene is expressed in the myeloid and lymphoid lineages of these
animals and an analysis of the sites of viral integration indicates that these lineages are
derived from the same primitive multipotent cells.
(neo) gene as a marker were used for long-term reconstitution of the haematopoietic system
of irradiated mice. The neo gene is expressed in the myeloid and lymphoid lineages of these
animals and an analysis of the sites of viral integration indicates that these lineages are
derived from the same primitive multipotent cells.
Abstract
Bone marrow cells infected with retroviral vectors carrying the bacterial neomycin resistance (neo) gene as a marker were used for long-term reconstitution of the haematopoietic system of irradiated mice. The neo gene is expressed in the myeloid and lymphoid lineages of these animals and an analysis of the sites of viral integration indicates that these lineages are derived from the same primitive multipotent cells.
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