Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation
S Gispert, D Del Turco, L Garrett, A Chen… - Molecular and Cellular …, 2003 - Elsevier
Alpha-synuclein was implicated in Parkinson's disease when missense mutations in the α-
synuclein gene were found in autosomal dominant Parkinson's disease and α-synuclein
was shown to be a major constituent of protein aggregates in sporadic Parkinson's disease
and other synucleinopathies. We have generated transgenic mice expressing A53T mutant
and wild-type human α-synuclein. The mutant transgenic protein was distributed abnormally
to the axons, perikarya, and dendrites of neurons in many brain areas. In electron …
synuclein gene were found in autosomal dominant Parkinson's disease and α-synuclein
was shown to be a major constituent of protein aggregates in sporadic Parkinson's disease
and other synucleinopathies. We have generated transgenic mice expressing A53T mutant
and wild-type human α-synuclein. The mutant transgenic protein was distributed abnormally
to the axons, perikarya, and dendrites of neurons in many brain areas. In electron …
