[HTML][HTML] α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor (AMPAR) endocytosis is essential for N-methyl-D-aspartate-induced …
Y Wang, W Ju, L Liu, S Fam, S D'Souza… - Journal of Biological …, 2004 - ASBMB
Excessive activation of the N-methyl-d-aspartate subtype glutamate receptor (NMDAR) is
thought to be involved in mediating programmed cell death (apoptosis) in numerous central
nervous diseases. However, the underlying mechanisms remain unknown. We report here
that stimulation of NMDARs activates intracellular signaling cascades leading to apoptosis
and facilitates clathrin-dependent endocytosis of α-amino-3-hydroxy-5-methylisoxazole-4-
propionic acid subtype glutamate receptors (AMPARs). Both broad spectrum inhibitors of …
thought to be involved in mediating programmed cell death (apoptosis) in numerous central
nervous diseases. However, the underlying mechanisms remain unknown. We report here
that stimulation of NMDARs activates intracellular signaling cascades leading to apoptosis
and facilitates clathrin-dependent endocytosis of α-amino-3-hydroxy-5-methylisoxazole-4-
propionic acid subtype glutamate receptors (AMPARs). Both broad spectrum inhibitors of …
