[HTML][HTML] ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery
CW Lai, JH Otero, LM Hendershot, E Snapp - Journal of Biological …, 2012 - ASBMB
Protein localization within cells regulates accessibility for interactions with co-factors and
substrates. The endoplasmic reticulum (ER) BiP co-factor ERdj4 is up-regulated by ER
stress and has been implicated in ER-associated degradation (ERAD) of multiple unfolded
secretory proteins. Several other ERdj family members tend to interact selectively with
nascent proteins, presumably because those ERdj proteins associate with the Sec61
translocon that facilitates entry of nascent proteins into the ER. How ERdj4 selects and …
substrates. The endoplasmic reticulum (ER) BiP co-factor ERdj4 is up-regulated by ER
stress and has been implicated in ER-associated degradation (ERAD) of multiple unfolded
secretory proteins. Several other ERdj family members tend to interact selectively with
nascent proteins, presumably because those ERdj proteins associate with the Sec61
translocon that facilitates entry of nascent proteins into the ER. How ERdj4 selects and …