GPS proteolytic cleavage of adhesion-GPCRs
The stability and functional diversity of proteins can be greatly modulated by
SRVWWUDQVODWLRQDO PRGLfiFDWLRQ 3URWHRO\WLF FOHDYDJH DW WKH* 3&5
SURWHRO\VLV VLWH* 36 KDV EHHQ LGHQWLfiHG DV DQ LQWULQVLF SURWHLQ
PRGLfiFDWLRQ SURFHVV RI PDQ\adhesion-GPCRs. In recent years, the conserved
cleavage site, molecular mechanism and the potential functional implication of the GPS
proteolysis have been gradually unveiled. However, many aspects of this unique cleavage …
SRVWWUDQVODWLRQDO PRGLfiFDWLRQ 3URWHRO\WLF FOHDYDJH DW WKH* 3&5
SURWHRO\VLV VLWH* 36 KDV EHHQ LGHQWLfiHG DV DQ LQWULQVLF SURWHLQ
PRGLfiFDWLRQ SURFHVV RI PDQ\adhesion-GPCRs. In recent years, the conserved
cleavage site, molecular mechanism and the potential functional implication of the GPS
proteolysis have been gradually unveiled. However, many aspects of this unique cleavage …
Abstract
The stability and functional diversity of proteins can be greatly modulated by SRVWWUDQVODWLRQDO PRGLfiFDWLRQ 3URWHRO\WLF FOHDYDJH DW WKH* 3&5 SURWHRO\VLV VLWH* 36 KDV EHHQ LGHQWLfiHG DV DQ LQWULQVLF SURWHLQ PRGLfiFDWLRQ SURFHVV RI PDQ\adhesion-GPCRs. In recent years, the conserved cleavage site, molecular mechanism and the potential functional implication of the GPS proteolysis have been gradually unveiled. However, many aspects of this unique cleavage reaction including its regulation, the relationship between the cleaved fragments and the functional pathways mediated by the cleaved receptor subunits, remain unanswered. Further LQYHVWLJDWLRQ RI WKH* 36 SURWHRO\WLF PRGLfiFDWLRQ VKDOO VKHG OLJKW RQ WKH ELRORJ\RI the adhesion-GPCRs.
Springer