Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0
I Kobsar, C Oetke, A Kroner, C Wessig… - Molecular and Cellular …, 2006 - Elsevier
Mouse mutants heterozygously deficient for the myelin component P0 mimic some forms of
inherited neuropathies in humans. We have previously shown that both T lymphocytes and
macrophages contribute to the demyelinating neuropathy. Both cell types appear to
influence each other mutually, ie, impaired T lymphocyte development in RAG-1-deficient P0
mutants leads to decreased macrophage numbers and retarded macrophage activation
causes reduced T lymphocyte numbers in the peripheral nerves of P0+/− mice. In the …
inherited neuropathies in humans. We have previously shown that both T lymphocytes and
macrophages contribute to the demyelinating neuropathy. Both cell types appear to
influence each other mutually, ie, impaired T lymphocyte development in RAG-1-deficient P0
mutants leads to decreased macrophage numbers and retarded macrophage activation
causes reduced T lymphocyte numbers in the peripheral nerves of P0+/− mice. In the …
