Origins of cardiac fibroblasts
EM Zeisberg, R Kalluri - Circulation research, 2010 - Am Heart Assoc
Circulation research, 2010•Am Heart Assoc
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are
indispensable for damage control and tissue remodeling on myocardial injury and principal
mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions,
cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that
cardiac fibroblasts are a heterogeneous population and likely derive from various distinct
tissue niches in health and disease. Here, we review our emerging understanding of where …
indispensable for damage control and tissue remodeling on myocardial injury and principal
mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions,
cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that
cardiac fibroblasts are a heterogeneous population and likely derive from various distinct
tissue niches in health and disease. Here, we review our emerging understanding of where …
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that cardiac fibroblasts are a heterogeneous population and likely derive from various distinct tissue niches in health and disease. Here, we review our emerging understanding of where cardiac fibroblasts come from, as well as how we can possibly use this knowledge to develop novel therapies for cardiac fibrosis.
Am Heart Assoc