[HTML][HTML] Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
ES Johnson, KR Lindblom, A Robeson… - Journal of Biological …, 2013 - ASBMB
The accumulation of long-chain fatty acids (LCFAs) in non-adipose tissues results in lipid-
induced cytotoxicity (or lipoapoptosis). Lipoapoptosis has been proposed to play an
important role in the pathogenesis of several metabolic diseases, including non-alcoholic
fatty liver disease, diabetes mellitus, and cardiovascular disease. In this report, we
demonstrate a novel role for caspase-2 as an initiator of lipoapoptosis. Using a
metabolomics approach, we discovered that the activation of caspase-2, the initiator of …
induced cytotoxicity (or lipoapoptosis). Lipoapoptosis has been proposed to play an
important role in the pathogenesis of several metabolic diseases, including non-alcoholic
fatty liver disease, diabetes mellitus, and cardiovascular disease. In this report, we
demonstrate a novel role for caspase-2 as an initiator of lipoapoptosis. Using a
metabolomics approach, we discovered that the activation of caspase-2, the initiator of …