[HTML][HTML] Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival
BGA Jawdeh, S Khan, I Deschênes, M Hoshi… - Journal of Biological …, 2011 - ASBMB
Tubular atrophy predicts chronic kidney disease progression, and is caused by proximal
tubular epithelial cell (PTC) apoptosis. The normally quiescent Na+/H+ exchanger-1 (NHE1)
defends against PTC apoptosis, and is regulated by PI (4, 5) P 2 binding. Because of the
vast array of plasma membrane lipids, we hypothesized that NHE1-mediated cell survival is
dynamically regulated by multiple anionic inner leaflet phospholipids. In membrane overlay
and surface plasmon resonance assays, the NHE1 C terminus bound phospholipids with …
tubular epithelial cell (PTC) apoptosis. The normally quiescent Na+/H+ exchanger-1 (NHE1)
defends against PTC apoptosis, and is regulated by PI (4, 5) P 2 binding. Because of the
vast array of plasma membrane lipids, we hypothesized that NHE1-mediated cell survival is
dynamically regulated by multiple anionic inner leaflet phospholipids. In membrane overlay
and surface plasmon resonance assays, the NHE1 C terminus bound phospholipids with …