[HTML][HTML] The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate β1 and β3 integrins
M Bouaouina, Y Lad, DA Calderwood - Journal of biological chemistry, 2008 - ASBMB
The activation of integrin adhesion receptors from low to high affinity in response to
intracellular cues controls cell adhesion and signaling. Binding of the cytoskeletal protein
talin to the β3 integrin cytoplasmic tail is required for β3 activation, and the integrin-binding
PTB-like F3 domain of talin is sufficient to activate β3 integrins. Here we report that, whereas
the conserved talin-integrin interaction is also required for β1 activation, and talin F3 binds
β1 and β3 integrins with comparable affinity, expression of the talin F3 domain is not …
intracellular cues controls cell adhesion and signaling. Binding of the cytoskeletal protein
talin to the β3 integrin cytoplasmic tail is required for β3 activation, and the integrin-binding
PTB-like F3 domain of talin is sufficient to activate β3 integrins. Here we report that, whereas
the conserved talin-integrin interaction is also required for β1 activation, and talin F3 binds
β1 and β3 integrins with comparable affinity, expression of the talin F3 domain is not …