[HTML][HTML] Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin [S]
AR Gingras, N Bate, BT Goult, B Patel, PM Kopp… - Journal of Biological …, 2010 - ASBMB
Talin is an adaptor protein that couples integrins to F-actin. Structural studies show that the
N-terminal talin head contains an atypical FERM domain, whereas the N-and C-terminal
parts of the talin rod include a series of α-helical bundles. However, determining the
structure of the central part of the rod has proved problematic. Residues 1359–1659 are
homologous to the MESDc1 gene product, and we therefore expressed this region of talin in
Escherichia coli. The crystal structure shows a unique fold comprised of a 5-and 4-helix …
N-terminal talin head contains an atypical FERM domain, whereas the N-and C-terminal
parts of the talin rod include a series of α-helical bundles. However, determining the
structure of the central part of the rod has proved problematic. Residues 1359–1659 are
homologous to the MESDc1 gene product, and we therefore expressed this region of talin in
Escherichia coli. The crystal structure shows a unique fold comprised of a 5-and 4-helix …