[HTML][HTML] Structural determinants of integrin binding to the talin rod
AR Gingras, WH Ziegler, AA Bobkov, MG Joyce… - Journal of biological …, 2009 - ASBMB
The adaptor protein talin serves both to activate the integrin family of cell adhesion
molecules and to couple integrins to the actin cytoskeleton. Integrin activation has been
shown to involve binding of the talin FERM domain to membrane proximal sequences in the
cytoplasmic domain of the integrin β-subunit. However, a second integrin-binding site (IBS2)
has been identified near the C-terminal end of the talin rod. Here we report the crystal
structure of IBS2 (residues 1974-2293), which comprises two five-helix bundles," IBS2 …
molecules and to couple integrins to the actin cytoskeleton. Integrin activation has been
shown to involve binding of the talin FERM domain to membrane proximal sequences in the
cytoplasmic domain of the integrin β-subunit. However, a second integrin-binding site (IBS2)
has been identified near the C-terminal end of the talin rod. Here we report the crystal
structure of IBS2 (residues 1974-2293), which comprises two five-helix bundles," IBS2 …