Changes in the G-protein-coupled receptor desensitization machinery during relapsing–progressive experimental allergic encephalomyelitis
A Vroon, MS Lombardi, A Kavelaars… - Journal of …, 2003 - Elsevier
G-protein-coupled receptors (GPCR) play an important role in inflammation. Their
responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and β-arrestins.
We show here that induction of experimental autoimmune encephalomyelitis (EAE) by
myelin oligodendrocyte glycoprotein (MOG) resulted in a profound decrease in GRK2 and
GRK6 protein in splenocytes during all phases of disease. GRK2 mRNA was also lower
during EAE, although the decrease in mRNA was less pronounced than the decrease in …
responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and β-arrestins.
We show here that induction of experimental autoimmune encephalomyelitis (EAE) by
myelin oligodendrocyte glycoprotein (MOG) resulted in a profound decrease in GRK2 and
GRK6 protein in splenocytes during all phases of disease. GRK2 mRNA was also lower
during EAE, although the decrease in mRNA was less pronounced than the decrease in …
