High serum levels of BAFF, APRIL, and TACI in common variable immunodeficiency
Common variable immunodeficiency (CVID) is characterized by low levels of immune
globulins and lack of antibody. Mutations in transmembrane activator and calcium-
modulating cyclophilin ligand (TACI), are found in 8–10%, associated with autoimmunity and
splenomegaly. Some patients with mutations had increased serum levels of TACI. Because
of this, and the prevalence of autoimmunity, splenomegaly, and lymphadenopathy, we
quantitated levels of TACI ligands, a proliferation inducing ligand (APRIL) and B cell …
globulins and lack of antibody. Mutations in transmembrane activator and calcium-
modulating cyclophilin ligand (TACI), are found in 8–10%, associated with autoimmunity and
splenomegaly. Some patients with mutations had increased serum levels of TACI. Because
of this, and the prevalence of autoimmunity, splenomegaly, and lymphadenopathy, we
quantitated levels of TACI ligands, a proliferation inducing ligand (APRIL) and B cell …