Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis
JG Schneider, Z Yang, MV Chakravarthy… - Journal of biological …, 2010 - ASBMB
Fatty acid metabolism is perturbed in atherosclerotic lesions, but whether it affects lesion
formation is unknown. To determine whether fatty acid synthesis affects atherosclerosis, we
inactivated fatty-acid synthase (FAS) in macrophages of apoE-deficient mice. Serum lipids,
body weight, and glucose metabolism were the same in FAS knock-out in macrophages
(FASKOM) and control mice, but blood pressure was lower in FASKOM animals.
Atherosclerotic extent was decreased 20–40% in different aortic regions of FASKOM as …
formation is unknown. To determine whether fatty acid synthesis affects atherosclerosis, we
inactivated fatty-acid synthase (FAS) in macrophages of apoE-deficient mice. Serum lipids,
body weight, and glucose metabolism were the same in FAS knock-out in macrophages
(FASKOM) and control mice, but blood pressure was lower in FASKOM animals.
Atherosclerotic extent was decreased 20–40% in different aortic regions of FASKOM as …
