[HTML][HTML] PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population
The prognosis of breast cancer patients is related to the degree of metastasis. However, the
mechanisms by which epithelial tumor cells escape from the primary tumor and colonize at a
distant site are not entirely understood. Here, we analyzed expression levels of pituitary
tumor-transforming gene-1 (PTTG1), a relatively uncharacterized oncoprotein, in patient-
derived breast cancer tissues with corresponding normal breast tissues. We found that
PTTG1 is highly expressed in breast cancer patients, compared with normal tissues. Also …
mechanisms by which epithelial tumor cells escape from the primary tumor and colonize at a
distant site are not entirely understood. Here, we analyzed expression levels of pituitary
tumor-transforming gene-1 (PTTG1), a relatively uncharacterized oncoprotein, in patient-
derived breast cancer tissues with corresponding normal breast tissues. We found that
PTTG1 is highly expressed in breast cancer patients, compared with normal tissues. Also …