Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14+ monocytes in frail older adults
T Qu, JD Walston, H Yang, NS Fedarko, QL Xue… - Mechanisms of ageing …, 2009 - Elsevier
Frailty has been increasingly recognized as an important clinical syndrome in old age. The
frailty syndrome is characterized by chronic inflammation, decreased functional and
physiologic reserve, and increased vulnerability to stressors, leading to disability and
mortality. However, molecular mechanisms that contribute to inflammation activation and
regulation in frail older adults have not been investigated. To begin to address this, we
conducted a pathway-specific gene array analysis of 367 inflammatory pathway genes by …
frailty syndrome is characterized by chronic inflammation, decreased functional and
physiologic reserve, and increased vulnerability to stressors, leading to disability and
mortality. However, molecular mechanisms that contribute to inflammation activation and
regulation in frail older adults have not been investigated. To begin to address this, we
conducted a pathway-specific gene array analysis of 367 inflammatory pathway genes by …