[HTML][HTML] AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
DR Bolster, SJ Crozier, SR Kimball… - Journal of Biological …, 2002 - ASBMB
AMP-activated protein kinase (AMPK) is viewed as an energy sensor that acts to modulate
glucose uptake and fatty acid oxidation in skeletal muscle. Given that protein synthesis is a
high energy-consuming process, it may be transiently depressed during cellular energy
stress. Thus, the intent of this investigation was to examine whether AMPK activation
modulates the translational control of protein synthesis in skeletal muscle. Injections of 5-
aminoimidazole-4-carboxamide 1-β-d-ribonucleoside (AICAR) were used to activate AMPK …
glucose uptake and fatty acid oxidation in skeletal muscle. Given that protein synthesis is a
high energy-consuming process, it may be transiently depressed during cellular energy
stress. Thus, the intent of this investigation was to examine whether AMPK activation
modulates the translational control of protein synthesis in skeletal muscle. Injections of 5-
aminoimidazole-4-carboxamide 1-β-d-ribonucleoside (AICAR) were used to activate AMPK …