Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat
B Andziak, TP O'Connor, R Buffenstein - Mechanisms of ageing and …, 2005 - Elsevier
The maximum lifespan of naked mole-rats (NMRs; Heterocephalus glaber) is greater than
that of any other rodent. These hystricognaths survive in captivity> 28 years, eight-times
longer than similar-sized mice. The present study tested if NMRs possess superior
antioxidant defenses compared to mice and if age-related interspecies changes in
antioxidants were evident. Activities of Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD,
catalase and cellular glutathione peroxidase (cGPx) were measured in livers of …
that of any other rodent. These hystricognaths survive in captivity> 28 years, eight-times
longer than similar-sized mice. The present study tested if NMRs possess superior
antioxidant defenses compared to mice and if age-related interspecies changes in
antioxidants were evident. Activities of Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD,
catalase and cellular glutathione peroxidase (cGPx) were measured in livers of …