A mutation in the gene gas-1 alters sensitivity to volatile anesthetics, fecundity, and life span
in the nematode Caenorhabditis elegans. gas-1 encodes a close homologue of the 49-kDa
iron protein subunit of Complex I of the mitochondrial electron transport chain from bovine
heart. gas-1 is widely expressed in the nematode neuromuscular system and in a
subcellular pattern consistent with that of a mitochondrial protein. Pharmacological studies
indicate thatgas-1 functions partially via presynaptic effects. In addition, a mutation in the gas …