The coupling between receptor-mediated Ca 2+ store release and the activation of" store-
operated" Ca 2+ entry channels is an important but so far poorly understood mechanism.
The transient receptor potential (TRP) superfamily of channels contains several members
that may serve the function of store-operated channels (SOCs). The 3, 5-bis (trifluoromethyl)
pyrazole derivative, BTP2, is a recently described inhibitor of SOC activity in T-lymphocytes.
We compared its action on SOC activation in a number of cell types and evaluated its …