Reactive oxygen species (ROS) are increasingly recognized as second messengers in
many cellular processes. While high concentrations of oxidants damage proteins, lipids and
DNA, ultimately resulting in cell death, selective and reversible oxidation of key residues in
proteins is a physiological mechanism that can transiently alter their activity and function.
Defects in ROS producing enzymes cause disturbed immune response and disease.
Changes in the intracellular free Ca2+ concentration are key triggers for diverse cellular …