Generation of HSP60-specific regulatory T cell and effect on atherosclerosis
K Yang, D Li, M Luo, Y Hu - Cellular immunology, 2006 - Elsevier
Although CD4+ CD25+ regulatory T cells are pivotal in the suppression of autoimmunity,
little is known about the effect of antigen-specific regulatory T cells on the formation of
atheromatous plaques. Here, we describe the induction of heat-shock protein 60 (HSP60)-
specific CD4+ CD25high T cells by rapamycin (RPM)-treated immature dendritic cells in vitro
and explore their effect on plaques in apolipoprotein E-deficient mice. Rapamycin-treated
bone marrow-derived dendritic cells (DC) were immature, expressing a low level of co …
little is known about the effect of antigen-specific regulatory T cells on the formation of
atheromatous plaques. Here, we describe the induction of heat-shock protein 60 (HSP60)-
specific CD4+ CD25high T cells by rapamycin (RPM)-treated immature dendritic cells in vitro
and explore their effect on plaques in apolipoprotein E-deficient mice. Rapamycin-treated
bone marrow-derived dendritic cells (DC) were immature, expressing a low level of co …
