Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, yet only a
fraction of infected persons ever develop cancer. The extensive genetic diversity inherent to
this pathogen has precluded comprehensive analyses of constituents that mediate
carcinogenesis. We previously reported that in vivo adaptation of a non-carcinogenic H.
pylori strain endowed the output derivative with the ability to induce adenocarcinoma,
providing a unique opportunity to identify proteins selectively expressed by an oncogenic H …