Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study
BACKGROUND: Atopy and asthma are commonly initiated during early life, and there is
increasing interest in the development of preventive treatments for at-risk children. However,
effective methods for assessing the level of risk in individual children are lacking.
OBJECTIVE: We sought to identify clinical and laboratory biomarkers in 2-year-olds that are
predictive of the risk for persistent atopy and wheeze at age 5 years. METHODS: We
prospectively studied 198 atopic family history–positive children to age 5 years. Clinical and …
increasing interest in the development of preventive treatments for at-risk children. However,
effective methods for assessing the level of risk in individual children are lacking.
OBJECTIVE: We sought to identify clinical and laboratory biomarkers in 2-year-olds that are
predictive of the risk for persistent atopy and wheeze at age 5 years. METHODS: We
prospectively studied 198 atopic family history–positive children to age 5 years. Clinical and …