Characterization of mammalian equilibrative nucleoside transporters (ENTs) by mass spectrometry
G Reyes, Z Naydenova, P Abdulla, M Chalsev… - Protein expression and …, 2010 - Elsevier
Equilibrative nucleoside transporters (ENTs) are integral membrane proteins that facilitate
the movement of nucleosides and hydrophilic nucleoside analog (NA) drugs across cell
membranes. ENTs are also targets for cardioprotectant drugs, which block re-uptake of the
purine nucleoside adenosine, thereby enhancing purinergic receptor signaling pathways.
ENTs are therefore important contributors to drug bioavailability and efficacy. Despite this
important clinical role, very little is known about the structure and regulation of ENTs …
the movement of nucleosides and hydrophilic nucleoside analog (NA) drugs across cell
membranes. ENTs are also targets for cardioprotectant drugs, which block re-uptake of the
purine nucleoside adenosine, thereby enhancing purinergic receptor signaling pathways.
ENTs are therefore important contributors to drug bioavailability and efficacy. Despite this
important clinical role, very little is known about the structure and regulation of ENTs …