[HTML][HTML] Characterization of 5, 6-and 8, 9-epoxyeicosatrienoic acids (5, 6-and 8, 9-EET) as potent in vivo angiogenic lipids
A Pozzi, I Macias-Perez, T Abair, S Wei, Y Su… - Journal of Biological …, 2005 - ASBMB
The cytochrome P450 arachidonic acid epoxygenase metabolites, the epoxyeicosatrienoic
acids (EETs) are powerful, nonregioselective, stimulators of cell proliferation. In this study we
compared the ability of the four EETs (5, 6-, 8, 9-, 11, 12-, and 14, 15-EETs) to regulate
endothelial cell proliferation in vitro and angiogenesis in vivo and determined the molecular
mechanism by which EETs control these events. Inhibition of the epoxygenase blocked
serum-induced endothelial cell proliferation, and exogenously added EETs rescued cell …
acids (EETs) are powerful, nonregioselective, stimulators of cell proliferation. In this study we
compared the ability of the four EETs (5, 6-, 8, 9-, 11, 12-, and 14, 15-EETs) to regulate
endothelial cell proliferation in vitro and angiogenesis in vivo and determined the molecular
mechanism by which EETs control these events. Inhibition of the epoxygenase blocked
serum-induced endothelial cell proliferation, and exogenously added EETs rescued cell …
