Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy
Alterations in the balance of cytoskeleton as well as energetic proteins are involved in the
cardiac remodeling occurring in dilated cardiomyopathy (DCM). We used two-dimensional
DIGE proteomics as a discovery approach to identify key molecular changes taking place in
a temporally controlled model of DCM triggered by cardiomyocyte-specific serum response
factor (SRF) knock-out in mice. We identified muscle creatine kinase (MCK) as the primary
down-regulated protein followed by α-actin and α-tropomyosin down-regulation leading to a …
cardiac remodeling occurring in dilated cardiomyopathy (DCM). We used two-dimensional
DIGE proteomics as a discovery approach to identify key molecular changes taking place in
a temporally controlled model of DCM triggered by cardiomyocyte-specific serum response
factor (SRF) knock-out in mice. We identified muscle creatine kinase (MCK) as the primary
down-regulated protein followed by α-actin and α-tropomyosin down-regulation leading to a …