Non-human primates: a model for tuberculosis research
JL Flynn, SV Capuano, D Croix, S Pawar, A Myers… - Tuberculosis, 2003 - Elsevier
A variety of animals have been used for tuberculosis research, and each animal model has
its strengths and weaknesses. We sought to develop a non-human primate model of
tuberculosis to model aspects of human tuberculosis that are difficult to model in other
animals, including the pathology in the lungs, various progression to disease, and
immunologic correlates of infection or disease that are likely to be similar in humans. To
date, we have infected 17 cynomolgus macaques (Macaca fasicularis) with a low dose (15 …
its strengths and weaknesses. We sought to develop a non-human primate model of
tuberculosis to model aspects of human tuberculosis that are difficult to model in other
animals, including the pathology in the lungs, various progression to disease, and
immunologic correlates of infection or disease that are likely to be similar in humans. To
date, we have infected 17 cynomolgus macaques (Macaca fasicularis) with a low dose (15 …
