Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia
G Xiang, T Seki, MD Schuster, P Witkowski… - Journal of Biological …, 2005 - ASBMB
Vitamin D3 up-regulated protein 1 (VDUP1) is a key mediator of oxidative stress on various
cellular processes via downstream effects on apoptosis signaling kinase 1 (ASK1) and p38
mitogen-activated protein kinase (MAPK). Here, we report that VDUP1 expression is
significantly increased in rat hearts following acute myocardial ischemia, suggesting it may
have important regulatory effects on cardiac physiological processes during periods of
oxidative stress. Transfection of H9C2 cardiomyoblasts with a sequence-specific VDUP1 …
cellular processes via downstream effects on apoptosis signaling kinase 1 (ASK1) and p38
mitogen-activated protein kinase (MAPK). Here, we report that VDUP1 expression is
significantly increased in rat hearts following acute myocardial ischemia, suggesting it may
have important regulatory effects on cardiac physiological processes during periods of
oxidative stress. Transfection of H9C2 cardiomyoblasts with a sequence-specific VDUP1 …
