[HTML][HTML] Nuclear role of IκB kinase-γ/NF-κB essential modulator (IKKγ/NEMO) in NF-κB-dependent gene expression
UN Verma, Y Yamamoto, S Prajapati… - Journal of Biological …, 2004 - ASBMB
The IκB kinase (IKK) complex, which is composed of the two kinases IKKα and IKKβ and the
regulatory subunit IKKγ/nuclear factor-κB (NF-κB) essential modulator (NEMO), is important
in the cytokine-induced activation of the NF-κB pathway. In addition to modulation of IKK
activity, the NF-κB pathway is also regulated by other processes, including the
nucleocytoplasmic shuttling of various components of this pathway and the post-
translational modification of factors bound to NF-κB-dependent promoters. In this study, we …
regulatory subunit IKKγ/nuclear factor-κB (NF-κB) essential modulator (NEMO), is important
in the cytokine-induced activation of the NF-κB pathway. In addition to modulation of IKK
activity, the NF-κB pathway is also regulated by other processes, including the
nucleocytoplasmic shuttling of various components of this pathway and the post-
translational modification of factors bound to NF-κB-dependent promoters. In this study, we …