[HTML][HTML] Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice
MA Pantaleo, A Astolfi, M Nannini, P Paterini… - British journal of …, 2008 - nature.com
British journal of cancer, 2008•nature.com
At present no reports on gene expression profiling of liver metastases from colorectal cancer
are available. We identified two different signatures using Affymetrix platform: epidermal
growth factor receptor pathway was upregulated in metachronous lesions, whereas the
pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or
metachronous liver metastases could be treated differently on the basis of different
molecular pathways.
are available. We identified two different signatures using Affymetrix platform: epidermal
growth factor receptor pathway was upregulated in metachronous lesions, whereas the
pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or
metachronous liver metastases could be treated differently on the basis of different
molecular pathways.
Abstract
At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.
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